American DNA

The population of the United States is shaped by centuries of migration, isolation, growth, and admixture between ancestors of global origins. We studied the ancestry and population structure of over 32,000 individuals in the US using genetic, ancestral birth origin, and geographic data from the National Geographic Genographic Project.

We identify migration routes and barriers that reflect historical demographic events. We also uncover the spatial patterns of relatedness in subpopulations through the combination of haplotype clustering, ancestral birth origin analysis, and local ancestry inference.